From Connecticut and New England: Take Interstate 84 west to Interstate 380 and continue west to Interstate 81 south. Follow 81 south to exit 185 (old exit 53)/Central Scranton Expressway. Take expressway approximately 1.7 miles to central city (do not take Cedar Avenue exit). Once in central city, bear right onto Jefferson Avenue two blocks to Mulberry Street. Make left onto Mulberry Street and drive four blocks to Penn Avenue. The Chamber is at 222 Mulberry Street at the corner of Mulberry Street and Penn Avenue (two-story brick building).

From Allentown, Philadelphia: Take the Northeast Extension of the Pennsylvania turnpike 476 (formerly route 9) north to exit 37/Wyoming Valley. After paying toll, continue traveling on the turnpike for a very short distance and then follow signs for Interstate 81 to Scranton. Take I-81 north to exit 185 (old exit 53)/Central Scranton Expressway. Take expressway approximately 1.7 miles to central city (do not take Cedar Avenue exit). Once in central city, bear right onto Jefferson Avenue two blocks to Mulberry Street. Make left onto Mulberry Street and drive four blocks to Penn Avenue. The Chamber is at 222 Mulberry Street at the corner of Mulberry Street and Penn Avenue (two-story brick building).

From Binghamton, Syracuse and Points North: Take Interstate 81 south to exit 191B (old exit 57B)/Scranton Expressway. Follow the expressway directly into central city (do not take the exit for 6w-11n/Clarks Summit). You will enter into central city on Mulberry Street. Take Mulberry Street two blocks to Penn Avenue. The Chamber is on the right at 222 Mulberry Street at the corner of Mulberry Street & Penn Avenue (two-story brick building).

From The Poconos, Northern New Jersey, and New York City: Take Interstate 80 west to Interstate 380 west to exit 20 (old exit 5)/Daleville/Route 307. Make a left at the end of the exit ramp and take Route 307 north approximately 9 miles to central city Scranton. Much of Route 307 will take you through a fairly rural area. Between exit 20 and central city you will pass through five traffic signals. At the fifth traffic signal (located at the bottom of the hill.) bear slightly right onto a small expressway which will take you a short distance into central city. As you arrive into central city bear right onto Jefferson Avenue. Take Jefferson Avenue two blocks to Mulberry Street. Make a left onto Mulberry Street and drive four blocks to Penn Avenue. The Chamber is at 222 Mulberry Street at the corner of Mulberry Street and Penn Avenue (two-story brick building).

From State College, Ohio and Points West: Take Interstate 80 east to Interstate 81 north to exit 185 (old exit 53)/Central Scranton Expressway. Take expressway approximately 1.7 miles to central city (do not take Cedar Avenue exit). Once in central city bear right onto Jefferson Avenue. Take Jefferson Avenue two blocks to Mulberry Street. Make a left onto Mulberry Street and drive four blocks to Penn Avenue. The Chamber is at 222 Mulberry Street at the corner of Mulberry Street and Penn Avenue (two-story brick building).